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Article

Origin and evolution of the zinc finger antiviral protein

26 Apr 2021

Abstract excerpt

The human zinc finger antiviral protein (ZAP) recognizes RNA by binding to CpG dinucleotides. Mammalian transcriptomes are CpG-poor, and ZAP may have evolved to exploit this feature to specifically target non-self viral RNA. Phylogenetic analyses reveal that ZAP and its paralogue PARP12 share an ancestral gene that arose prior to extensive eukaryote divergence, and the ZAP lineage diverged from the PARP12 lineage...

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PMID: 33901262
DOI: 10.1371/journal.ppat.1009545

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