Article

The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2

2020-05-07

Abstract excerpt

COVID-19 can lead to acute respiratory syndrome, which can be due to dysregulated immune signaling. We analyze the distribution of CpG dinucleotides, a pathogen-associated molecular pattern, in the SARS-CoV-2 genome. We find that the CpG content, which we characterize by a force parameter that accounts for statistical constraints acting on the genome at the nucleotidic and amino-acid levels, is, on average, low co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93f43c71-cb9e-5934-b3f9-c503add270ee
DOI: 10.1101/2020.05.06.074039

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The heterogeneous landscape and early evolution of pathogen-associated CpG dinucleotides in SARS-CoV-2DOI 10.1101/2020.05.06.074039Read

The Heterogeneous Landscape and Early Evolution of Pathogen-Associated CpG Dinucleotides in SARS-CoV-2Semantic proximity Read

Intra-genome variability in the dinucleotide composition of SARS-CoV-2Semantic proximity Read

The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSemantic proximity Read

Intra-genome variability in the dinucleotide composition of SARS-CoV-2Semantic proximity Read

SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci.Semantic proximity Read

Coronavirus genomes carry the signatures of their habitatsSemantic proximity Read

An accelerating, decreasing phylogenetic trend in SARS-CoV-2 genome compositional heterogeneity during the pandemicSemantic proximity Read

Multi-site co-mutations and 5’UTR CpG immunity escape drive the evolution of SARS-CoV-2Semantic proximity Read

The substitution spectra of coronavirus genomes.Semantic proximity Read

Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design.Semantic proximity Read

Mutation patterns of human SARS-COV-2 and bat RaTG13 coronaviruses genomes are strongly biased towards C>U indicating rapid evolution in their hostsSemantic proximity Read

Extreme Genomic CpG Deficiency in SARS-CoV-2 and Evasion of Host Antiviral DefenseSemantic proximity Read