Article

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

2024-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Zoonotic viruses are an omnipresent threat to global health. Influenza A virus (IAV) transmits between birds, livestock, and humans. Proviral host factors involved in the cross-species interface are well known. Less is known about antiviral mechanisms that suppress IAV zoonoses. We observed CpG dinucleotide depletion in human IAV relative to avian IAV. Notably, human ZAP selectively depletes CpG...

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Literature Corpus work: 52c83c89-624a-5824-a36f-dc11942cbd07
DOI: 10.1101/2024.12.23.629495

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