Article

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

2020-05-09

Abstract excerpt

CpG dinucleotides are under-represented in the genomes of single stranded RNA viruses, and coronaviruses, including SARS-CoV-2, are no exception to this. Artificial modification of CpG frequency is a valid approach for live attenuated vaccine development, and if this is to be applied to SARS-CoV-2, we must first understand the role CpG motifs play in regulating SARS-CoV-2 replication. Accordingly, the CpG composit...

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Literature Corpus work: c32f282a-399e-5ef9-8c44-8f0243c36314
DOI: 10.1101/2020.05.08.083816

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