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Article

Intra-genome variability in the dinucleotide composition of SARS-CoV-2

1 Jul 2020

Abstract excerpt

Abstract CpG dinucleotides are under-represented in the genomes of single-stranded RNA viruses, and SARS-CoV-2 is no exception to this. Artificial modification of CpG frequency is a valid approach for live attenuated vaccine development; if this is to be applied to SARS-CoV-2, we must first understand the role CpG motifs play in regulating SARS-CoV-2 replication. Accordingly, the CpG composition of the SARS-CoV-2...

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Identifiers

PMID: 33029383
DOI: 10.1093/ve/veaa057

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