Article

Origin and evolution of the Zinc Finger Antiviral Protein

2020-12-05

Abstract excerpt

The human zinc finger antiviral protein (ZAP) recognizes RNA by binding to CpG dinucleotides. Mammalian transcriptomes are CpG-poor, and ZAP may have evolved to exploit this feature to specifically target non-self viral RNA. Phylogenetic analyses reveal that ZAP and its paralogue PARP12 share an ancestral gene that arose prior to extensive eukaryote divergence, and the ZAP lineage diverged from the PARP12 line...

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Literature Corpus work: f104e2c7-b4d6-515c-a83b-ebd692d5fd2f
DOI: 10.1101/2020.12.04.412510

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