Article
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.
Frontiers in endocrinology - 1 Jan 2023
González-Moro Itziar, Rojas-Márquez Henar, Sebastian-delaCruz Maialen, Mentxaka-Salgado Jon, Olazagoitia-Garmendia Ane, Mendoza Luis Manuel, Lluch Aina, Fantuzzi Federica, Lambert Carmen, Ares Blanco Jessica, Marselli Lorella, Marchetti Piero, Cnop Miriam, Delgado Elías, Fernández-Real José Manuel, Ortega Francisco José, Castellanos-Rubio Ainara, Santin Izortze
Abstract excerpt
Introduction: Most of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions of the human genome. Many of these variants have been predicted to impact the expression and function of long non-coding RNAs (lncRNA), but the contribution of these molecules to the development of complex diseases remains to be clarified. Methods: Here, we performed a genetic association study between a...
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