Article
Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants.
Genes and immunity - 1 Jan 2013
de Jong V M, Zaldumbide A, van der Slik A R, Persengiev S P, Roep B O, Koeleman B P C
Abstract excerpt
The genetic variation causal for predisposition to type 1 diabetes (T1D) remains unidentified for the majority of known T1D risk loci. MicroRNAs function as post-transcriptional gene regulators by targeting microRNA-binding sites in the 3' untranslated regions (UTR) of mRNA. Genetic variation within the 3'-UTR of T1D-associated genes may contribute to T1D development by altering microRNA-mediated gene regulation....
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