Article
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation.
Nature genetics - 1 Jul 2016
Zheng Jian, Huang Xudong, Tan Wen, Yu Dianke, Du Zhongli, Chang Jiang, Wei Lixuan, Han Yaling, Wang Chengfeng, Che Xu, Zhou Yifeng, Miao Xiaoping, Jiang Guoliang, Yu Xianjun, Yang Xianghong, Cao Guangwen, Zuo Chaohui, Li Zhaoshen, Wang Chunyou, Cheung Siu Tim, Jia Yongfeng, Zheng Xiongwei, Shen Hongbing, Wu Chen, Lin Dongxin
Abstract excerpt
Genome-wide association studies have identified several loci associated with pancreatic cancer risk; however, the mechanisms by which genetic factors influence the development of sporadic pancreatic cancer remain largely unknown. Here, by using genome-wide association analysis and functional characterization, we identify a long intergenic noncoding RNA (lincRNA), LINC00673, as a potential tumor suppressor whose...
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