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Article

DNMT3A (R882) mutation features and prognostic effect in acute myeloid leukemia in Coexistent with NPM1 and FLT3 mutations.

Hematology/oncology and stem cell therapy - 1 Jun 2018

Kumar Dushyant, Mehta Anurag, Panigrahi Manoj Kumar, Nath Sukanta, Saikia Kandarpa Kumar

Abstract excerpt

OBJECTIVE/BACKGROUND: In the absence of high-risk cytogenetic, DNMT3A (DNA Methyltransferase 3a) mutation status has an impact on outcome in the presence of FLT3 (FMS-like Tyrosine Kinase3) and/or NPM1 (Nucleophosmin). In this study, we focus on the features and effect of DNMT3A (R882) mutation in acute myeloid leukemia (AML) in the presence or absence of NPM1 and FLT3 mutations. METHODS: A total of 174...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29079128
DOI: 10.1016/j.hemonc.2017.09.004

Genes

FLT3
NPM1

Provenance

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