Article
4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 8 Apr 2020
Bollmann Eva, Schreiber Julian Alexander, Ritter Nadine, Peischard Stefan, Ho Huyen Tran, Wünsch Bernhard, Strünker Timo, Meuth Sven, Budde Thomas, Strutz-Seebohm Nathalie, Seebohm Guiscard
Abstract excerpt
BACKGROUND/AIMS: The cardiac current IKs is carried by the KCNQ1/KCNE1-channel complex. Genetic aberrations that affect the activity of KCNQ1/KCNE1 can lead to the Long QT Syndrome 1 and 5 and, thereby, to a predisposition to sudden cardiac death. This might be prevented by pharmacological modulation of KCNQ1/KCNE1. The prototypic KCNQ1/KCNE1 activator 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS)...
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