Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).

doi:10.1111/bph.70008

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Article

Rescue of loss-of-function long QT syndrome-associated mutations in KV7.1/KCNE1 by the endocannabinoid N-arachidonoyl-L-serine (ARA-S).

British journal of pharmacology - 1 Jul 2025

Hiniesto-Iñigo Irene, Sridhar Akshay, Louradour Julien, De la Cruz Alicia, Lundholm Siri, Jauregi-Miguel Amaia, Giannetti Federica, Sala Luca, Odening Katja E, Larsson H Peter, Ottosson Nina E, Liin Sara I

Abstract excerpt

BACKGROUND AND PURPOSE: Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding KV7.1/KCNE1 are the most frequent, with channel loss-of-function contributing to LQTS. The endocannabinoid N-arachidonoyl-L-serine (ARA-S) has been shown to facilitate...

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Topics

Long QT Syndrome
Animals
Humans
KCNQ1 Potassium Channel
Xenopus laevis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Potassium Channels, Voltage-Gated

Endocannabinoids

Serine

Mutation

Arachidonic Acids

Loss of Function Mutation

Oocytes

Female

HEK293 Cells

Source

Open in PubMed

Identifiers

PMID: 40083204
DOI: 10.1111/bph.70008

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