Article
A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.
Epilepsia - 1 Apr 2018
Atkin Talia A, Maher Chani M, Gerlach Aaron C, Gay Bryant C, Antonio Brett M, Santos Sonia C, Padilla Karen M, Rader JulieAnn, Krafte Douglas S, Fox Matthew A, Stewart Gregory R, Petrovski Slavé, Devinsky Orrin, Might Matthew, Petrou Steven, Goldstein David B
Abstract excerpt
OBJECTIVE: Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds. Here, we demonstrate the feasibility of a more comprehensive approach using high-throughput screening to identify inhibitors of a gain-of-function mutation in the SCN8A gene associated with severe pediatric epilepsy. METHODS: We developed cellular models...
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