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Article

Interaction between Apolipoprotein E and Butyrylcholinesterase Genes on Risk of Alzheimer's Disease in a Prospective Cohort Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Chuang Yi-Fang, Varma Vijay, An Yang, Tanaka Toshiko, Davatzikos Christos, Resnick Susan M, Thambisetty Madhav

Abstract excerpt

BACKGROUND: An epistatic interaction between the ɛ4 allele of apolipoprotein E (APOEɛ4) gene and the K-variant of butyrylcholinesterase (BCHE-K) genes has been previously reported to increase risk of Alzheimer's disease (AD). However, these observations were largely from case-control studies with small sample sizes. OBJECTIVE: To examine the interaction between APOEɛ4 and BCHE-K on: 1) the risk of incident AD and...

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Identifiers

PMID: 32250307
DOI: 10.3233/JAD-191335
PMCID: PMC10845166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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