Article
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease.
Pharmacogenetics and genomics - 1 Apr 2008
Lane Roger, Feldman Howard H, Meyer Joanne, He Yunsheng, Ferris Steven H, Nordberg Agneta, Darreh-Shori Taher, Soininen Hilkka, Pirttilä Tuula, Farlow Martin R, Sfikas Nikolaos, Ballard Clive, Greig Nigel H
Abstract excerpt
OBJECTIVE: To evaluate the synergistic effects of the apolipoprotein E (APOE) epsilon4 and butyrylcholinesterase K-variant (BCHE-K) alleles on progression to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). METHODS: This was a post-hoc exploratory analysis from a 3-4-year, randomized, placebo-controlled study of rivastigmine in participants with MCI (InDDEx study). Participants who...
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