Article
Evaluation of sequencing strategies for whole-genome imputation with hybrid peeling.
Genetics, selection, evolution : GSE - 6 Apr 2020
Ros-Freixedes Roger, Whalen Andrew, Gorjanc Gregor, Mileham Alan J, Hickey John M
Abstract excerpt
BACKGROUND: For assembling large whole-genome sequence datasets for routine use in research and breeding, the sequencing strategy should be adapted to the methods that will be used later for variant discovery and imputation. In this study, we used simulation to explore the impact that the sequencing strategy and level of sequencing investment have on the overall accuracy of imputation using hybrid peeling, a...
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