Article
Fast imputation using medium or low-coverage sequence data.
BMC genetics - 14 Jul 2015
VanRaden Paul M, Sun Chuanyu, O'Connell Jeffrey R
Abstract excerpt
BACKGROUND: Accurate genotype imputation can greatly reduce costs and increase benefits by combining whole-genome sequence data of varying read depth and array genotypes of varying densities. For large populations, an efficient strategy chooses the two haplotypes most likely to form each genotype and updates posterior allele probabilities from prior probabilities within those two haplotypes as each individual's...
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