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Article

Extending long-range phasing and haplotype library imputation algorithms to large and heterogeneous datasets.

Genetics, selection, evolution : GSE - 8 Jul 2020

Money Daniel, Wilson David, Jenko Janez, Whalen Andrew, Thorn Steve, Gorjanc Gregor, Hickey John M

Abstract excerpt

BACKGROUND: We describe the latest improvements to the long-range phasing (LRP) and haplotype library imputation (HLI) algorithms for successful phasing of both datasets with one million individuals and datasets genotyped using different sets of single nucleotide polymorphisms (SNPs). Previous publicly available implementations of the LRP algorithm implemented in AlphaPhase could not phase large datasets due to...

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PMID: 32640985
DOI: 10.1186/s12711-020-00558-2
PMCID: PMC7346379

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