Article
A beginner's guide to low-coverage whole genome sequencing for population genomics.
Molecular ecology - 1 Dec 2021
Lou Runyang Nicolas, Jacobs Arne, Wilder Aryn P, Therkildsen Nina Overgaard
Abstract excerpt
Low-coverage whole genome sequencing (lcWGS) has emerged as a powerful and cost-effective approach for population genomic studies in both model and nonmodel species. However, with read depths too low to confidently call individual genotypes, lcWGS requires specialized analysis tools that explicitly account for genotype uncertainty. A growing number of such tools have become available, but it can be difficult to...
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