Article
Novel methods for genotype imputation to whole-genome sequence and a simple linear model to predict imputation accuracy.
BMC genetics - 27 Dec 2017
Larmer Steven G, Sargolzaei Mehdi, Brito Luiz F, Ventura Ricardo V, Schenkel Flávio S
Abstract excerpt
BACKGROUND: Accurate imputation plays a major role in genomic studies of livestock industries, where the number of genotyped or sequenced animals is limited by costs. This study explored methods to create an ideal reference population for imputation to Next Generation Sequencing data in cattle. METHODS: Methods for clustering of animals for imputation were explored, using 1000 Bull Genomes Project sequence data...
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