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Article

Genotype imputation to increase sample size in pedigreed populations.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013

Hickey John M, Cleveland Matthew A, Maltecca Christian, Gorjanc Gregor, Gredler Birgit, Kranis Andreas

Abstract excerpt

Genotype imputation is a cost-effective way to increase the power of genomic selection or genome-wide association studies. While several genotype imputation algorithms are available, this chapter focuses on a heuristic algorithm, as implemented in the AlphaImpute software. This algorithm combines long-range phasing, haplotype library imputation, and segregation analysis and it is specifically designed to work...

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PMID: 23756901
DOI: 10.1007/978-1-62703-447-0_17

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