Article
A strategy to improve phasing of whole-genome sequenced individuals through integration of familial information from dense genotype panels.
Genetics, selection, evolution : GSE - 16 May 2017
Faux Pierre, Druet Tom
Abstract excerpt
BACKGROUND: Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information. With whole-genome sequence (WGS) data, relatively small samples of reference individuals are generally sequenced due to prohibitive sequencing costs, thus only a limited amount of familial...
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