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Article

Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity.

Lupus science & medicine - 9 Apr 2026

Lindelöf Linnea, Garred Peter, Hong Mun-Gwan, Wahl Vælum Sasha, Holten Petersen Lotte, Leonard Dag, Sayadi Ahmed, Oke Vilija, Niewold Timothy B, Diaz-Gallo Lina-Marcela, Saevarsdottir Saedis, Gunnarsson Iva, Svenungsson Elisabet, Eriksson Oskar

Abstract excerpt

OBJECTIVE: SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear. Lectin pathway-dependent complement activation is initiated by pattern-recognition molecules complexed with mannose-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated proteins (MAPs). Here, we combined biochemical and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41956715
DOI: 10.1136/lupus-2025-001890
PMCID: PMC13084892

Genes

MASP1
MASP2
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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