Article
Lectin pathway of complement in SLE: MAP-1 as a marker of haematological manifestations and elevated type I interferon activity.
Lupus science & medicine - 9 Apr 2026
Lindelöf Linnea, Garred Peter, Hong Mun-Gwan, Wahl Vælum Sasha, Holten Petersen Lotte, Leonard Dag, Sayadi Ahmed, Oke Vilija, Niewold Timothy B, Diaz-Gallo Lina-Marcela, Saevarsdottir Saedis, Gunnarsson Iva, Svenungsson Elisabet, Eriksson Oskar
Abstract excerpt
OBJECTIVE: SLE is a systemic autoimmune disease in which the complement system plays a key pathogenic role, yet the contribution of the lectin pathway remains unclear. Lectin pathway-dependent complement activation is initiated by pattern-recognition molecules complexed with mannose-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated proteins (MAPs). Here, we combined biochemical and...
Topics
- Humans
- Lupus Erythematosus, Systemic
- Female
- Mannose-Binding Protein-Associated Serine Proteases
- Interferon Type I
- Autoantibodies
- Biomarkers
- Male
- Complement Pathway, Mannose-Binding Lectin