Article
Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Aug 2011
Vasconcelos Luydson Richardson Silva, Fonseca Juliana Pereira Lopes, do Carmo Rodrigo Feliciano, de Mendonça Taciana Furtado, Pereira Valeria Rêgo Alves, Lucena-Silva Norma, Pereira Leila Maria Moreira Beltrão, Moura Patrícia, Cavalcanti Maria do Socorro de Mendonça
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) activates the complement system promoting opsonophagocytosis, which could represent an advantage for Mycobacterium leprae, an intracellular pathogen. Therefore, a single nucleotide polymorphism (SNP) in the MBL2 gene associated with low levels of MBL could confer protection against the development of leprosy disease. METHODS: In this study, we investigated SNPs of the MBL2...
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