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Article

The R-spondin protein family.

Genome biology - 1 Jan 2012

de Lau Wim B M, Snel Berend, Clevers Hans C

Abstract excerpt

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin signaling pathway. These proteins are approximately 35 kDa, and are characterized by two amino-terminal furin-like repeats, which are necessary and sufficient for Wnt signal potentiation, and a thrombospondin domain situated more towards the carboxyl terminus that can bind matrix glycosaminoglycans and/or proteoglycans....

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Source

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Identifiers

PMID: 22439850
DOI: 10.1186/gb-2012-13-3-242
PMCID: PMC3439965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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