Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk

Abstract excerpt

<h4>Objectives</h4> To investigate the biological and clinical relevance of knee alignment in osteoarthritis by integrating population-scale imaging, genome-wide association, and functional genetic analyses. <h4>Methods</h4> Femorotibial angle was derived from dual-energy X-ray absorptiometry scans in UK Biobank using machine-learning methods. Associations with knee and hip osteoarthritis outcomes were assessed....

Topics

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• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genotype
• Molecular Epidemiology
• Osteoarthritis
• Osteoarthritis, Hip
• Osteoarthritis, Knee
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

e986b8e4-0658-558e-b511-79213f212d2b

DOI

10.64898/2026.06.23.26356332