Article
Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells.
British journal of cancer - 1 May 2020
Kajanova Ivana, Zatovicova Miriam, Jelenska Lenka, Sedlakova Olga, Barathova Monika, Csaderova Lucia, Debreova Michaela, Lukacikova Lubomira, Grossmannova Katarina, Labudova Martina, Golias Tereza, Svastova Eliska, Ludwig Andreas, Muller Petr, Vojtesek Borivoj, Pastorek Jaromir, Pastorekova Silvia
Abstract excerpt
BACKGROUND: Carbonic anhydrase IX (CA IX) is a hypoxia-induced enzyme regulating tumour pH and facilitating cell migration/invasion. It is primarily expressed as a transmembrane cell-surface protein, but its ectodomain can be shed by ADAM17 to extracellular space. This study aims to elucidate the impact of CA IX shedding on cancer cells. METHODS: We generated a non-shed CA IX mutant by deletion of amino acids...
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