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Article

Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9.

Gastroenterology - 1 Dec 2002

Gut Marta Ortova, Parkkila Seppo, Vernerová Zdeòka, Rohde Elvira, Závada Jan, Höcker Michael, Pastorek Jaromír, Karttunen Tuomo, Gibadulinová Adriana, Závadová Zuzana, Knobeloch Klaus-Peter, Wiedenmann Bertram, Svoboda Jan, Horak Ivan, Pastoreková Silvia

Abstract excerpt

BACKGROUND & AIMS: Carbonic anhydrase (CA) IX is a highly active enzyme with adhesion capacity that is functionally implicated in acid-base balance and intercellular communication. It is normally present in basolateral membranes of gastrointestinal epithelial cells and ectopically expressed in various carcinomas. To show its physiologic relevance, we have cloned the Car9 gene and generated CA IX-deficient mice....

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Identifiers

PMID: 12454846
DOI: 10.1053/gast.2002.37052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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