Article
Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors.
Cancer research - 15 Dec 2011
Ditte Peter, Dequiedt Franck, Svastova Eliska, Hulikova Alzbeta, Ohradanova-Repic Anna, Zatovicova Miriam, Csaderova Lucia, Kopacek Juraj, Supuran Claudiu T, Pastorekova Silvia, Pastorek Jaromir
Abstract excerpt
In the hypoxic regions of a tumor, carbonic anhydrase IX (CA IX) is an important transmembrane component of the pH regulatory machinery that participates in bicarbonate transport. Because tumor pH has implications for growth, invasion, and therapy, determining the basis for the contributions of CA IX to the hypoxic tumor microenvironment could lead to new fundamental and practical insights. Here, we report that...
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