Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.

doi:10.1016/j.febslet.2009.10.060

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Article

Intact intracellular tail is critical for proper functioning of the tumor-associated, hypoxia-regulated carbonic anhydrase IX.

FEBS letters - 19 Nov 2009

Hulikova Alzbeta, Zatovicova Miriam, Svastova Eliska, Ditte Peter, Brasseur Robert, Kettmann Richard, Supuran Claudiu T, Kopacek Juraj, Pastorek Jaromir, Pastorekova Silvia

Abstract excerpt

Carbonic anhydrase IX (CA IX) is a tumor-associated, hypoxia-induced enzyme involved in pH regulation and cell adhesion. Its catalytically active ectodomain (ECD) is linked to a transmembrane region and a short intracellular (IC) tail. Removal of the IC tail causes intracellular localization of CA IX. Mutations of basic amino acids within IC do not perturb the membrane position, but reduce shedding of the CA IX...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Antigens, Neoplasm
Binding Sites
Carbonic Anhydrase IX
Carbonic Anhydrases
Cell Hypoxia
Cell Line
Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydrogen-Ion Concentration

Immunoblotting

Membrane Proteins

Microscopy, Confocal

Molecular Sequence Data

Mutation

Neoplasms

Source

Open in PubMed

Identifiers

PMID: 19861127
DOI: 10.1016/j.febslet.2009.10.060

Genes

Provenance

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