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Carbonic anhydrase VIII as a regulator of intracellular calcium signaling: mechanistic insights and implications in human disease.

Molecular biology reports - 10 Jun 2026

Aspatwar Ashok

Abstract excerpt

Carbonic anhydrases are classically defined as zinc-dependent enzymes that catalyze the reversible hydration of carbon dioxide and play essential roles in acid-base homeostasis. However, carbonic anhydrase VIII (CA VIII) represents a catalytically inactive member of this family due to the absence of one of the three histidine residues required for enzymatic activityStructural analyses further indicate that,...

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Identifiers

PMID: 42268453
DOI: 10.1007/s11033-026-12124-y
PMCID: PMC13253706

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