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Cancer-Associated Carbonic Anhydrases and Their Inhibition

1 Mar 2008

Abstract excerpt

Cells of the growing tumor tissue are exposed to physiological stresses connected with insufficient delivery of oxygen (hypoxia) and accumulation of acidic products of the glycolytic metabolism (acidosis). Adaptation to these microenvironmental stresses involves remodeling of the cellular expression program mediated by hypoxia-inducible factor (HIF), which activates broad array of genes functionally involved in...

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Identifiers

PMID: 18336315
DOI: 10.2174/138161208783877893

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