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Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

15 May 2025

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer, for which targeted treatment is currently lacking. Carbonic anhydrase IX (CAIX) is a known cancer target due to its selective overexpression in hypoxia, a hallmark of many solid cancers including TNBC. This study aimed to develop a robust murine TNBC cell line 4T1-based model system that could be used in the comprehensive...

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PMID: 40371725
DOI: 10.1002/2211-5463.70052

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