Article
A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes.
Nature immunology - 1 Apr 2020
Emming Stefan, Bianchi Niccolò, Polletti Sara, Balestrieri Chiara, Leoni Cristina, Montagner Sara, Chirichella Michele, Delaleu Nicolas, Natoli Gioacchino, Monticelli Silvia
Abstract excerpt
Understanding the mechanisms that modulate helper T lymphocyte functions is crucial to decipher normal and pathogenic immune responses in humans. To identify molecular determinants influencing the pathogenicity of T cells, we separated ex vivo-isolated primary human memory T lymphocytes on the basis of their ability to produce high levels of inflammatory cytokines. We found that the inflammatory,...
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