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Article

Human TH17 cells are long-lived effector memory cells.

Science translational medicine - 12 Oct 2011

Kryczek Ilona, Zhao Ende, Liu Yan, Wang Yin, Vatan Linhua, Szeliga Wojciech, Moyer Jeffrey, Klimczak Aleksandra, Lange Andrzej, Zou Weiping

Abstract excerpt

T helper 17 (TH17) cells have been shown to contribute to multiple disease systems. However, the functional phenotype and survival pattern of TH17 cells as well as the underlying mechanisms that control TH17 cells have been poorly investigated in humans, significantly hampering the clinical targeting of these cells. Here, we studied human TH17 cells in the pathological microenvironments of graft-versus-host...

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Identifiers

PMID: 21998407
DOI: 10.1126/scitranslmed.3002949
PMCID: PMC3345568

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