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Article

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.

Cell reports - 19 Sept 2017

Kumar Brahma V, Ma Wenji, Miron Michelle, Granot Tomer, Guyer Rebecca S, Carpenter Dustin J, Senda Takashi, Sun Xiaoyun, Ho Siu-Hong, Lerner Harvey, Friedman Amy L, Shen Yufeng, Farber Donna L

Abstract excerpt

Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to infection and vaccination, while in humans, the existence and properties of TRMs remain unclear. Here, we use a unique human tissue resource to determine whether human tissue memory T cells constitute a distinct subset in diverse mucosal and lymphoid tissues. We identify a core transcriptional profile within the CD69+ subset of...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28930685
DOI: 10.1016/j.celrep.2017.08.078
PMCID: PMC5646692

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