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Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

6 Mar 2024

Abstract excerpt

Abstract T peripheral helper (Tph) cells are thought to contribute to extra-follicular B cell activation and play a pathogenic role in autoimmune diseases. However, the role of Tph subsets is not fully elucidated. Here, we investigate the immunological functions of Tph subsets and their involvement in systemic lupus erythematosus (SLE). We have defined four Tph subsets (Tph1: CXCR3 + CCR6 − , Tph2: CXCR3 − CCR6 −...

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PMID: 38448723
DOI: 10.1038/s42003-024-05989-x

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