Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development.

Differentiation; research in biological diversity - 1 Jan 2000

Wang Wenfeng, Zheng Xiaoling, Song Hejie, Yang Junjie, Liu Xiangyang, Wang Ye, Zhang Min, Zhang Zhen

Abstract excerpt

Laterality disease is frequently associated with congenital heart disease (CHD). However, it is unclear what is behind this association, a pleiotropic effect of common genetic causes of laterality diseases or the impact of abnormal left-right patterning on the downstream cardiovascular development. MEGF8 is a disease gene of Carpenter syndrome characterized by defective lateralization and CHD. Here we performed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Body Patterning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to Gene Deletion

Share to Heart Defects, Congenital

Share to Membrane Proteins

Source

Identifiers

PMID: 32203821
DOI: 10.1016/j.diff.2020.03.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development.PMID 32203821Read ↗

The genetic landscape of cardiovascular left-right patterning defects.Semantic proximity Read ↗

Left-right patterning in congenital heart disease beyond heterotaxy.Semantic proximity Read ↗

Loss of Cited2 causes congenital heart disease by perturbing left–right patterning of the body axisSemantic proximity Read ↗

The genetics of left-right development and heterotaxiaSemantic proximity Read ↗

A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2‐Mycn pathway during cardiac morphogenesisSemantic proximity Read ↗

The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1).Semantic proximity Read ↗

The Axenfeld-Rieger syndrome gene <i>FOXC1</i> contributes to left-right patterningSemantic proximity Read ↗

<i>Fgf8</i>is required for pharyngeal arch and cardiovascular development in the mouseSemantic proximity Read ↗

Congenital heart disease and the specification of left-right asymmetrySemantic proximity Read ↗

Mutations in multidomain protein MEGF8 identify a Carpenter syndrome subtype associated with defective lateralization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.