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Article

The genetics of left-right development and heterotaxia

1 Dec 1996

Abstract excerpt

Looping of the primitive heart tube is one of the earliest and most crucial steps in cardiac morphogenesis. Cardiac looping is dependent on normal left-right development, and defects in left-right development result in both heterotaxia and complex congenital heart disease. Single gene defects result in the wide spectrum of heterotaxy phenotypes, and conversely, different gene defects result in similar heterotaxy...

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PMID: 9090782
DOI: 10.1016/s0146-0005(96)80070-x

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