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Article

Congenital heart disease and the specification of left-right asymmetry

10 Mar 2012

Abstract excerpt

Complex congenital heart disease (CHD) is often seen in conjunction with heterotaxy, the randomization of left-right visceral organ situs. However, the link between cardiovascular morphogenesis and left-right patterning is not well understood. To elucidate the role of left-right patterning in cardiovascular development, we examined situs anomalies and CHD in mice with a loss of function allele of Dnaic1, a dynein...

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PMID: 22408017
DOI: 10.1152/ajpheart.01118.2011

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