Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2‐Mycn pathway during cardiac morphogenesis

1 Jan 2021

Abstract excerpt

A basic helix-loop-helix transcription factor Hey2 is expressed in the ventricular myocardium and endocardium of mouse embryos, and Hey2 null mice die perinatally showing ventricular septal defect, dysplastic tricuspid valve and hypoplastic right ventricle. In order to understand region-specific roles of Hey2 during cardiac morphogenesis, we generated Hey2 conditional knockout (cKO) mice using Mef2c-AHF-Cre,...

Source

Identifiers

PMID: 33410138
DOI: 10.1111/dgd.12707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2‐Mycn pathway during cardiac morphogenesisPMID 33410138Read ↗

Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and DiseaseSemantic proximity Read ↗

GATA4 Is a Direct Transcriptional Activator of <i>Cyclin D2</i> and <i>Cdk4</i> and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived MyocardiumSemantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.Semantic proximity Read ↗

BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heartSemantic proximity Read ↗

MEF2C regulates outflow tract alignment and transcriptional control of <i>Tdgf1</i>Semantic proximity Read ↗

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.Semantic proximity Read ↗

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factorsSemantic proximity Read ↗

Canonical Wnt signaling functions in second heart field to promote right ventricular growth.Semantic proximity Read ↗

Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract.Semantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.