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The Axenfeld-Rieger syndrome gene <i>FOXC1</i> contributes to left-right patterning

2020-05-28

Abstract excerpt

Normal body situs requires precise spatiotemporal expression of the Nodal-Lefty-Pitx2 cascade in the lateral plate mesoderm. The ultimate output of this patterning is establishment of the left-right axis, which provides vital cues for correct organ formation and function. Mutations, deletions and duplications in PITX2 and FOXC1 lead to the rare genetic disease Axenfeld-Rieger syndrome (ARS). While situs defects...

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Literature Corpus work
dcc39331-3af7-5e78-ae7a-e9282f61fedb
DOI
10.1101/2020.05.28.120915
Open publication

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The Axenfeld-Rieger syndrome gene <i>FOXC1</i> contributes to left-right patterningDOI 10.1101/2020.05.28.120915
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