Article
The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning.
Genes - 26 Jan 2021
Chrystal Paul W, French Curtis R, Jean Francesca, Havrylov Serhiy, van Baarle Suey, Peturson Ann-Marie, Xu Pengfei, Crump J Gage, Pilgrim David B, Lehmann Ordan J, Waskiewicz Andrew J
Abstract excerpt
Precise spatiotemporal expression of the Nodal-Lefty-Pitx2 cascade in the lateral plate mesoderm establishes the left-right axis, which provides vital cues for correct organ formation and function. Mutations of one cascade constituent PITX2 and, separately, the Forkhead transcription factor FOXC1 independently cause a multi-system disorder known as Axenfeld-Rieger syndrome (ARS). Since cardiac involvement is an...
Topics
- Alleles
- Animals
- Anterior Eye Segment
- Computational Biology
- Disease Models, Animal
- Eye Abnormalities
- Eye Diseases, Hereditary
- Forkhead Transcription Factors
- Gene Expression Profiling
- Genetic Association Studies