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Article

PEST domain NOTCH mutations confer a poor relapse free survival in pediatric T-ALL: Data from a tertiary care centre in India.

Blood cells, molecules & diseases - 1 May 2020

Bhatia Prateek, Totadri Sidharth, Singh Minu, Sharma Praveen, Trehan Amita, Bansal Deepak, Jain Richa, Varma Neelam, Sachdeva Manupdesh S, Patra Nilamani

Abstract excerpt

A comprehensive genotype-phenotype analysis of pediatric T-ALL data was performed. 33 confirmed pediatric (≤12 y) T-ALL samples were evaluated for oncogenic transcripts: TLX-1, TLX-3, common fusion of STIL-TAL1, NOTCH1 mutations and copy number variations (CNVs). Mean WBC was 235.69 × 103/μL. TLX1 and TLX-3 overexpression detected in 1 (3%) and 7 (21%) patients and STIL-TAL1 in 8 (27%). NOTCH1 mutations were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 32179411
DOI: 10.1016/j.bcmd.2020.102419

Genes

NOTCH1
STIL
TAL1
CDKN2A
CDKN2B
TLX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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