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Article

Mutations in the HD and PEST domain of Notch-1 receptor in T-cell acute lymphoblastic leukemia: report of novel mutations from Indian population.

Oncology research - 1 Jan 2010

Bhanushali Aparna A, Babu Suresh, Thangapandi Veera Raghavan, Pillai Renjith, Chheda Pratiksha, Das Bibhu R

Abstract excerpt

Notch-1 is a transmembrane receptor protein that directs T-cell differentiation. Gain-of-function mutations in Notch-1 have been reported in more than 50% of human T-cell acute lymphoblastic leukemia (T-ALL). The current study was undertaken to characterize mutations in the heterodimerization (HD) domain and proline, glutamic acid, serine, threonine-rich (PEST) domain of the Notch-1 receptor. RNA was isolated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21302811
DOI: 10.3727/096504010x12864748215007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the HD and PEST domain of Notch-1 receptor in T-cell acute lymphoblastic leukemia: report of novel mutations from Indian population.PMID 21302811Read ↗

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[Characteristics of NOTCH1 mutation in adult T-cell acute lymphoblastic leukemia].Semantic proximity Read ↗

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Identification of novel NOTCH1 mutations: increasing our knowledge of the NOTCH signaling pathway.Semantic proximity Read ↗

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