Article
Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL.
Disease markers - 1 Jan 2010
Erbilgin Yucel, Sayitoglu Muge, Hatirnaz Ozden, Dogru Omer, Akcay Arzu, Tuysuz Gulen, Celkan Tiraje, Aydogan Gonul, Salcioglu Zafer, Timur Cetin, Yuksel-Soycan Lebriz, Ure Umit, Anak Sema, Agaoglu Leyla, Devecioglu Omer, Yildiz Inci, Ozbek Ugur
Abstract excerpt
The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T-ALL patients. In this study, the mutation analysis of NOTCH1 and FBXW7...
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