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Article

Comprehensive Analysis of NOTCH1 Mutations in Indian Pediatric ALL Patients: Clinical and Molecular Insights.

Asian Pacific journal of cancer prevention : APJCP - 1 Oct 2025

Padmakumar Amritha, Thankamony Priyakumari, Gopinath Preethi, Radhakrishnan Chandraprabha Vineetha, Thampirajan Vimala Devi Akhila Raj, John Anitha Geetha Raj, Mohanan Sreelatha Mahitha, Padmakumar Devipriya, Kumarapillai Mohanan Nair Jagathnath Krishna, Lathika Surendran Suraj, Sreedharan Hariharan

Abstract excerpt

BACKGROUND: Acute Lymphoblastic Leukemia (ALL) is a prevalent childhood malignancy characterized by abnormal lymphoid cell proliferation. Despite treatment advancements, relapse remains problematic, necessitating improved prognostic markers. NOTCH1 mutations, particularly in T-cell ALL (T-ALL), have been implicated in ALL pathogenesis. METHODS: We examined the correlation between NOTCH1 mutations and clinical...

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Source

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Identifiers

PMID: 41148611
DOI: 10.31557/APJCP.2025.26.10.3711
PMCID: PMC12905812

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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