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Article

Identification of novel NOTCH1 mutations: increasing our knowledge of the NOTCH signaling pathway.

Pediatric blood & cancer - 1 May 2014

Gallo Llorente L, Luther H, Schneppenheim R, Zimmermann M, Felice M, Horstmann M A

Abstract excerpt

BACKGROUND: Alterations in the NOTCH1 signaling pathway are found in about 60% of pediatric T-ALL, but its impact on prognosis remains unclear. PROCEDURE: We extended the previously published CoALL cohort (n = 74) to a larger cohort (n = 127) and additionally included 38 Argentine patients from ALL IC-BFM to potentially identify novel mutations and decipher a stronger discriminatory effect on the...

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Source

Identifiers

PMID: 24249312
DOI: 10.1002/pbc.24852

Genes

NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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