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Article

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia.

BMC cancer - 6 Jan 2012

Mansur Marcela Braga, Hassan Rocio, Barbosa Thayana C, Splendore Alessandra, Jotta Patricia Y, Yunes José Andrés, Wiemels Joseph L, Pombo-de-Oliveira Maria S

Abstract excerpt

BACKGROUND: Molecular alterations occur frequently in T-ALL and the potential impact of those abnormalities on outcome is still controversial. The current study aimed to test whether NOTCH1 mutations and additional molecular abnormalities would impact T-ALL outcome in a series of 138 T-ALL paediatric cases. METHODS: T-ALL subtypes, status of SIL-TAL1 fusion, ectopic expression of TLX3, and mutations in FBXW7,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22225590
DOI: 10.1186/1471-2407-12-9
PMCID: PMC3305583

Genes

NOTCH1
TAL1
EFS
KRAS
PTEN
TLX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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