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Programmed cell death-1-modified pig developed using electroporation-mediated gene editing for in vitro fertilized zygotes.

In vitro cellular & developmental biology. Animal - 1 Aug 2024

Nguyen Thanh-Van, Do Lanh Thi Kim, Lin Qingyi, Nagahara Megumi, Namula Zhao, Wittayarat Manita, Hirata Maki, Otoi Takeshige, Tanihara Fuminori

Abstract excerpt

Programmed cell death-1 (PD-1) is an immunoinhibitory receptor required to suppress inappropriate immune responses such as autoimmunity. Immune checkpoint antibodies that augment the PD-1 pathway lead to immune-related adverse events (irAEs), organ non-specific side effects due to autoimmune activation in humans. In this study, we generated a PD-1 mutant pig using electroporation-mediated introduction of the...

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Identifiers

PMID: 38485817
DOI: 10.1007/s11626-024-00869-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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